A northern district of East Kilbride, Calderwood lies 1¼ miles (2 km) northeast of the town centre. The district developed on the estate of the former Calderwood Castle, a property of the Maxwells, which was demolished in 1955.
Moncrieff Church of Scotland, founded in the old village of East Kilbride in 1843, transferred to Calderwood in 1959. The district also benefits from a Baptist Church. There are five primary schools located here (Greenburn, Halfmerke, Hunter, Long Calderwood and Maxwellton), together with Hunter High School.
Brothers and notable surgeons Dr William Hunter (1718-83) and Dr John Hunter (1728-93) were born at Long Calderwood, and the Hunter House Museum tells their story.