A section of the town of Blantyre nearest to the River Clyde, Low Blantyre lies opposite Bothwell and 2½ miles (4 km) northwest of Hamilton. It was laid out as a model village in a meander in the river to accommodate workers for a large water-powered cotton-mill established here in 1785. African explorer David Livingstone was born here in Shuttle Row in 1813, in a building now the property of the National Trust for Scotland and operated as the David Livingstone Centre which explains his life and work.
Blantyre railway station is located here, on the Argyle line which runs southeast from Glasgow Central station to Motherwell and Lanark.