A location, former estate and housing development on the border of Midlothian and the City of Edinburgh, 4 miles (6.5 km) southeast of the centre of Edinburgh, the original hamlet of Edmonstone remains in NW Danderhall, around the Edmonstone Inn.
The estate has been developed to include housing, the Edinburgh BioQuarter, Little France Park and part of the site of Edinburgh Royal Infirmary. The estate was the property of the Edmonstone family from 1248 and they built a castle in the vicinity, of which there is now no trace. They are said to have come to Scotland in 1067 with St Margaret (1045-93). The property passed to the Raits in the early 17th Century and then by marriage to John Wauchope of Niddrie (1633 - 1709) in 1671, who became a Lord of Session the following year. In the 18th century the Wauchopes built a mansion, set in a designed landscape, on the site of the old castle. This was demolished in the 1950s, but a ruined stable block, ice-house, walled-garden and gatehouse remain. Edmonstone Colliery once lay immediately to the north, dating from the early 18th century and linked by a waggonway to Millerhill in 1818.
The 2020s saw houses for rent developed within the former walled garden by Hillcrest Housing Association (known as Foxglove Close) and private housing on Tweedsmuir Drive to the west.