Associated with the settlement of the same name in South Lanarkshire, the Douglases were the pre-eminent family of South-West Scotland, with significant power and political influence from the 12th C. The family includes the Earls of Douglas (the 'Black Douglases'), Earls of Angus (the 'Red Douglases'), the Earls of Morton, the Viscounts of Drumlanrig and the Earls, Marquesses and Dukes of Queensberry.
The Dukes of Hamilton have been Douglas-Hamiltons since the Duchess Anne married the third son of the 1st Marquess of Douglas in 1656.