Muthill is a parish, which lies in Perth and Kinross Council Area, some 5 miles (8 km) southwest of Crieff and 9 miles (14 km) west of Auchterarder in Perth and Kinross.
It is located in the old county of Perthshire, which disappeared following the Local Government (Scotland) Act 1974.
The parish has an area of 106.4 sq. km (41.1 sq. miles). Muthill has 9 neighbouring parishes; namely Ardoch, Blackford, Callander, Comrie, Crieff, Dunblane & Lecropt, Kilmadock, Monzievaird & Strowan and Trinity Gask. The boundaries of this parish were modified among significant changes recommended by the Boundary Commissioners after the Local Government (Scotland) Act 1889.